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KMID : 1134820070360111385
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 11 p.1385 ~ p.1390
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Cytotoxic Effects of Decursin from Angelica gigas Nakai in Human Cancer Cells
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Park Kyung-wuk
Choi Sa-Ra
Shon Mi-Yae
Jeong Il Yun
Kang Kap-Suk
Lee Sung-Tae
Shim Ki-Hwan
Seo Kwon-Il
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Abstract
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Anticarcinogenic-active compound was isolated and purified from Angelica gigas Nakai. The compound was identified as decursin (C₁?H₂?O?; molecular weight 328) by mass, IR spectrophotometry, ¹H-NMR and ¹³C- NMR. The proliferation decreased in a dose dependant fashion in the MCF-7 cells treated with decursin for 24 hours over the concentration of 20 ㎍/㎖. The IC?? value of the decursin treatment for 24 hours were 31.04, 33.60, 27,24, 20.45 ㎍/㎖ in the SW480, 293, HepG2 and MCF-7 cells, respectively. The growth inhibitory effect was stronger in the MCF-7 cells compared to other cells including 293 of human normal cells. The chromatin condensation, apoptotic body formation and DNA fragmentation were examined in the cells treated with decursin. These results suggest that decursin from Angelica gigas Nakai inhibited the growth through apoptosis in MCF-7 cells.
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KEYWORD
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Angelica gigas Nakai, decursin, MCF-7, cytotoxic activity, apoptosis
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